Epigenetic-Featured Topics

EPIGENETICS

Epigenetics is the study of how cells control gene activity without changing the DNA sequence. Many types of epigenetic processes have been identified, including methylation, acetylation, phosphorylation, ubiquitylation, sumoylation, and chromatin modification. To Date, a wide variety of illnesses, behaviors, and other health indicators already have some level of evidence linking them with epigenetic mechanisms, including cancers of almost all types, cognitive dysfunction, and respiratory, cardiovascular, reproductive, autoimmune, and neurobehavioral illnesses.

Learn mroe about ABclonal epigenetics antibodies and reagents

ABclonal Epigenetic Solutions

ABclonal continually focuses on research development in the field of epigenetics and is committed to providing the highest quality research tools. Our product portfolio includes kits, NGS, biochemical reagents, and antibodies that can cover almost all aspects of epigenetic research to provide you with one-stop scientific research services.

NGS library
prep kits

Histone modification
antibodies

Antibodies against
histone modifying enzymes

Antibodies against
transcription factors

DNA methylation
antibodies

RNA modification
antibodies

ABclonal develops and produces a series of recombinant monoclonal antibodies, including ChIP, ChIP-seq, and CUT&Tag, and has undergone multiple rigorous in-house validations. Our product portfolio can cover almost all aspects of epigenetic research to provide you with one-stop scientific research services.

NGS library prep kits

Library construction is a key step in next-generation sequencing. High-quality library construction kits can generate high-yield and -coverage libraries. Our continual innovation and optimization in raw materials, enzymes, and the systems make the workflow easier and faster. Our kits can be used in a broad range of sample types, from cell lines to fresh tissue, formalin-fixed paraffin-embedded (FFPE) samples, blood, and other challenging sample types.

Histone modification antibodies

Histone modification represents the classical epigenetic mechanisms, including histone methylation, acetylation, phosphorylation, ubiquitination, etc. The study of histone modification mechanism and regulation can help us understand epigenetic patterns, and provide novel tools for the treatment of diseases and the development of new drugs.

Histone H3 Rabbit mAb

A17562

Acetyl-Histone H3-K27 Rabbit mAb

A2771

TriMethyl-Histone H3-K27 Rabbit mAb

A22006

Target

Cat.No.

Product Name

Application

Reactivity

H2AX	A11412	Histone H2AX Rabbit mAb	WB,IHC-P,ChIP	Human,Mouse,Rat,Other (Wide Range)
H4C14	A15233	Acetyl-Histone H4-K5 Rabbit pAb	WB,IHC-P,ChIP	Human, Mouse, Rat, Other (Wide Range)
Histone H2B	A15619	Acetyl-Histone H2B-K12 Rabbit pAb	WB,IHC-P,IF/ICC,ChIP	Human, Mouse, Rat
Histone H2B	A15621	Acetyl-Histone H2B-K5 Rabbit pAb	WB,IHC-P,IF/ICC,IP,ChIP	Human, Mouse, Rat
Histone H3	A16078	Acetyl-Histone H3-K4 Rabbit pAb	WB,IF/ICC,ChIP	Human, Mouse, Rat, Other (Wide Range)
H3C1	A17562	Histone H3 Rabbit mAb	WB,IHC-P,IF/ICC,ChIP	Human,Mouse,Rat,Oryza sativa,Other (Wide Range)
Histone H3	A18154	Acetyl-Histone H3-K23 Rabbit pAb	WB,IHC-P,IF/ICC,ChIP	Human, Mouse, Rat, Other (Wide Range)
Histone H3	A19645	MonoMethyl-Histone H3-R2 Rabbit mAb	DB,WB,ChIP,CUT&Tag	Human,Mouse,Rat,Other (Wide Range)
H3C1	A20184	Acetyl-Histone H3-K27 Rabbit pAb	DB,WB,ChIP	Human, Mouse, Rat, Other (Wide Range)
Histone H3	A20379	TriMethyl-Histone H3-K36 Rabbit mAb	DB,WB,IP,IHC-P,ChIP,ChIP-seq	Human,Mouse,Rat,Other (Wide Range)
H3-4	A20680	MonoMethyl-Histone H3-K18 Rabbit mAb	DB,WB,IHC-P,IP,IF/ICC,ChIP,CUT&Tag	Human, Mouse, Rat
H3C1	A20734	MonoMethyl-Histone H3-K9 Rabbit mAb	DB,WB,IHC-P,IF/ICC,ChIP,CUT&Tag	Human, Mouse, Rat, Other (Wide Range)
H3C1	A20735	Acetyl-Histone H3-K18 Rabbit mAb	DB,WB,IHC-P,ChIP,CUT&Tag,ChIP-seq	Human, Mouse, Rat, Other (Wide Range)
H3C1	A21107	Acetyl-Histone H3-K9 Rabbit mAb	DB,WB,IHC-P,IF/ICC,IP,ChIP,CUT&Tag	Human,Mouse,Rat,Other (Wide Range)
H3C1	A21223	MonoMethyl-Histone H3-K79 Rabbit mAb	DB,WB,IHC-P,ChIP,ChIP-seq	Human,Mouse,Rat,Other (Wide Range)
H3-4	A22006	TriMethyl-Histone H3-K27 Rabbit mAb	DB,WB,IF/ICC,IP,ChIP	Human,Mouse,Rat,Other (Wide Range)
H3-4	A2355	MonoMethyl-Histone H3-K4 Rabbit pAb	WB,IHC-P,IF/ICC,IP,ChIP,ChIP-seq	Human, Mouse, Rat, Other (Wide Range)
H3-4	A2356	DiMethyl-Histone H3-K4 Rabbit pAb	WB,IHC-P,IF/ICC,IP,ChIP,ChIP-seq	Human, Mouse, Rat, Other (Wide Range)
H3-4	A2357	TriMethyl-Histone H3-K4 Rabbit pAb	DB,WB,IHC-P,ChIP,ChIP-seq	Human, Mouse, Rat, Other (Wide Range)
H3-4	A2358	MonoMethyl-Histone H3-K9 Rabbit pAb	DB,WB,IHC-P,IF/ICC,ChIP,ChIP-seq	Human, Mouse, Rat, Other (Wide Range)
H3-4	A2359	DiMethyl-Histone H3-K9 Rabbit pAb	WB,IHC-P,IF/ICC,IP,ChIP,ChIP-seq	Human, Mouse, Rat, Other (Wide Range)
H3-4	A2360	TriMethyl-Histone H3-K9 Rabbit pAb	DB,WB,IHC-P,IF/ICC,ChIP	Human, Mouse, Rat, Other (Wide Range)
H3C1	A2361	MonoMethyl-Histone H3-K27 Rabbit pAb	DB,WB,IHC-P,IF/ICC,ChIP	Human, Mouse, Rat, Other (Wide Range)
H3-4	A2362	DiMethyl-Histone H3-K27 Rabbit pAb	WB,IF/ICC,IP,ChIP,ChIP-seq	Human, Mouse, Rat, Other (Wide Range)
H3-4	A2364	MonoMethyl-Histone H3-K36 Rabbit pAb	WB,IF/ICC,IP,ChIP,ChIP-seq	Human, Mouse, Rat, Other (Wide Range)
H3-4	A2365	DiMethyl-Histone H3-K36 Rabbit pAb	WB,IHC-P,IF/ICC,IP,ChIP,ChIP-seq	Human, Mouse, Rat, Other (Wide Range)
H3-4	A2366	TriMethyl-Histone H3-K36 Rabbit pAb	WB,IHC-P,IF/ICC,IP,ChIP,ChIP-seq	Human, Mouse, Rat, Other (Wide Range)
H3-4	A2367	MonoMethyl-Histone H3-K79 Rabbit pAb	WB,IHC-P,IF/ICC,IP,ChIP,ChIP-seq	Human, Mouse, Rat, Other (Wide Range)
H3-4	A2368	DiMethyl-Histone H3-K79 Rabbit pAb	WB,IHC-P,IF/ICC,IP,ChIP,ChIP-seq	Human, Mouse, Rat, Other (Wide Range)
H3-4	A2369	TriMethyl-Histone H3-K79 Rabbit pAb	DB,WB,IHC-P,IF/ICC,ChIP	Human, Mouse, Rat, Other (Wide Range)
H4C14	A2371	DiMethyl-Histone H4-K20 Rabbit pAb	WB,IHC-P,IF/ICC,IP,ChIP,ChIP-seq	Human, Mouse, Rat, Other (Wide Range)
H3-4	A2373	Symmetric DiMethyl-Histone H3-R2 Rabbit pAb	WB,IHC-P,IF/ICC,IP,ChIP,ChIP-seq	Human, Mouse, Rat, Other (Wide Range)
H3-4	A2374	Symmetric DiMethyl-Histone H3-R8 Rabbit pAb	WB,IHC-P,IF/ICC,IP,ChIP,ChIP-seq	Human, Mouse, Rat, Other (Wide Range)
H3C12	A3151	MonoMethyl-Histone H3-R17 Rabbit pAb	WB,IHC-P,IF/ICC,IP,ChIP,ChIP-seq	Human, Mouse, Rat, Other (Wide Range)
H3-4	A3154	MonoMethyl-Histone H3-R2 Rabbit pAb	WB,IF/ICC,ChIP	Human, Mouse, Rat, Other (Wide Range)
H3-4	A3155	Asymmetric DiMethyl-Histone H3-R2 Rabbit pAb	WB,IF/ICC,IP,ChIP,ChIP-seq	Human, Mouse, Rat, Other (Wide Range)
H3-4	A3156	MonoMethyl-Histone H3-R8 Rabbit pAb	WB,IHC-P,IF/ICC,IP,ChIP,ChIP-seq	Human, Mouse, Rat, Other (Wide Range)
H3-3A	A4835	Histone H3.3 Rabbit mAb	WB,IHC-P,IP,ChIP,ChIP-seq	Human, Mouse, Rat, Other (Wide Range)
H3-4	A5278	DiMethyl-Histone H3-K14 Rabbit pAb	WB,IF/ICC,IP,ChIP,ChIP-seq	Human, Mouse, Rat, Other (Wide Range)
H3-4	A5279	TriMethyl-Histone H3-K14 Rabbit pAb	WB,IF/ICC,IP,ChIP,ChIP-seq	Human, Mouse, Rat, Other (Wide Range)
Histone H4	A5280	Acetyl-Histone H4-K16 Rabbit pAb	WB,IF/ICC	Human, Mouse, Rat, Other (Wide Range)
H3-4	A7253	Acetyl-Histone H3-K27 Rabbit pAb	WB,IHC-P,IF/ICC,IP,ChIP,ChIP-seq	Human, Mouse, Rat, Other (Wide Range)
Histone H3	A7255	Acetyl-Histone H3-K9 Rabbit pAb	WB,IHC-P,IF/ICC,IP,ChIP,ChIP-seq	Human, Mouse, Rat, Other (Wide Range)
Histone H3	A7256	Acetyl-Histone H3-K56 Rabbit pAb	WB,IF/ICC,ChIP	Human, Mouse, Rat, Other (Wide Range)
H3C12	A7257	Acetyl-Histone H3-K18 Rabbit pAb	WB,IHC-P,IF/ICC,IP,ChIP,ChIP-seq	Human, Mouse, Rat, Other (Wide Range)
H4C1	A7258	Acetyl-Histone H4-K8 Rabbit pAb	WB,IHC-P,IF/ICC,IP,ChIP,ChIP-seq	Human, Mouse, Rat, Other (Wide Range)
H3-4	A7262	TriMethyl-Histone H3-K56 Rabbit pAb	WB,IF/ICC,IP,ChIP,ChIP-seq	Human, Mouse, Rat, Other (Wide Range)

Antibodies against histone modifying enzymes

Histone modifying enzymes catalyze the addition or removal of an array of covalent modifications in histones and non-histone proteins and play an important role in gene regulation, tumor cell proliferation and apoptosis, and DNA repair. These efforts will be crucial to developing therapeutics that target histone modifying enzymes within specific complexes in order to treat human disease.

A19571

[KO Validated] HDAC1 Rabbit mAb

A19577

EZH2/KMT6 Rabbit mAb

A4755

KDM5A Rabbit mAb

Target

Cat.No.

Product Name

Application

Reactivity

ELP3	A0020	KAT9/Elp3 Rabbit mAb	WB,IHC-P	Human, Mouse, Rat
MST1	A0109	MSP/MST1 Rabbit mAb	WB,IHC-P,IF/ICC	Human, Mouse, Rat
UBE2B	A0503	UBE2B Rabbit mAb	WB,IHC-P	Human, Mouse, Rat
PRKCA	A11107	PKC alpha Rabbit mAb	WB,IHC-P,IP	Human, Mouse, Rat
DOT1L	A12329	Dot1L/KMT4 Rabbit mAb	WB,IP	Human, Mouse
HDAC7	A13008	HDAC7 Rabbit mAb	WB	Human, Mouse, Rat
HDAC4	A13510	HDAC4 Rabbit mAb	WB	Human
EHMT2	A19288	EHMT2 Rabbit mAb	WB,IHC-P	Human, Mouse, Rat
PRMT5	A19533	PRMT5 Rabbit mAb	WB,IHC-P	Human, Mouse, Rat
AURKB	A19539	Aurora B Rabbit mAb	WB,IF/ICC	Human, Mouse, Rat
HDAC1	A19571	[KO Validated] HDAC1 Rabbit mAb	WB,IHC-P,IF/ICC	Human, Mouse, Rat
HDAC2	A19626	HDAC2 Rabbit mAb	WB,IP	Human, Mouse, Rat
SIRT1	A19667	[KO Validated] SIRT1 Rabbit mAb	WB,IF/ICC	Human
RING1	A19750	RING1A Rabbit mAb	WB,IHC-P,IP	Human
CARM1	A21106	[KO Validated] PRMT4/CARM1 Rabbit mAb	WB,IP	Human, Mouse, Rat
HDAC9	A2226	HDAC9 Rabbit mAb	WB,IHC-P,IF/ICC	Human, Rat
SMYD3	A2262	SMYD3 Rabbit mAb	WB,IF/ICC	Human, Mouse, Rat
PRKD1	A2417	PKC mu Rabbit mAb	WB	Human, Mouse, Rat
KAT8	A3390	KAT8/MYST1/MOF Rabbit mAb	WB,IHC-P,IF/ICC	Human, Mouse
RNF2	A3564	RING1B/RNF2 Rabbit mAb	WB,IP	Human, Mouse, Rat
HDAC6	A3572	HDAC6 Rabbit mAb	WB,IHC-P,IP	Human
SUV39H2	A3705	KMT1B / SUV39H2 Rabbit mAb	WB	Human
SIRT2	A3967	SIRT2 Rabbit mAb	WB	Human
CHEK1	A4194	Chk1 Rabbit mAb	WB,IHC-P	Human
HAT1	A4423	KAT1/HAT1 Rabbit mAb	WB,IHC-P,IF/ICC	Human, Mouse, Rat
PAK2	A4553	PAK2 Rabbit mAb	WB,IF/ICC	Human, Mouse, Rat
KDM5A	A4755	KDM5A Rabbit mAb	WB,IP,ChIP	Human, Mouse, Rat
RNF20	A4784	RNF20 Rabbit mAb	WB	Human, Mouse
BIRC5	A4838	Survivin Rabbit mAb	WB	Mouse, Rat
PRKCE	A4998	PKC epsilon Rabbit mAb	WB	Mouse
PRMT6	A5085	PRMT6 Rabbit mAb	WB	Human, Mouse, Rat
KDM4B	A6670	KDM4B/JMJD2B Rabbit mAb	WB,IF/ICC,IP,ChIP	Human, Mouse, Rat
KDM1A	A8711	KDM1 / LSD1 Rabbit mAb	WB,IHC-P	Human
HDAC8	A8865	[KO Validated] HDAC8 Rabbit mAb	WB,IHC-P,IF/ICC,IP	Human, Mouse, Rat
NCOA1	A9058	KAT13A / SRC1 Rabbit mAb	WB,IP	Human
SETD7	A9225	SETD7 Rabbit mAb	WB	Human, Mouse, Rat
KDM4A	A9267	KDM4A Rabbit mAb	WB,IP	Human, Mouse
BAZ1B	A9519	WSTF Rabbit mAb	WB	Human, Mouse, Rat
PRKCG	A9565	PKC gamma Rabbit mAb	WB	Mouse, Rat
RNF40	A9598	RNF40 Rabbit mAb	WB,IHC-P	Human, Mouse
WDR77	A9921	WDR77 Mouse mAb	WB,IF/ICC	Human, Mouse, Rat
SIRT1	AP0976	Phospho-SIRT1-S47 Rabbit mAb	WB	Human, Mouse
PRKCA	AP1045	Phospho-PKC alpha-T638 Rabbit mAb	WB	Human, Mouse, Rat
CHEK1	AP1047	Phospho-Chk1-S296 Rabbit mAb	WB	Human

Antibodies against transcription factors

Transcription factors (TFs) are at the center of the broad regulatory network orchestrating gene expression programs that elicit different biological responses. For a long time, TFs have been considered as potent drug targets due to their implications in the pathogenesis of a variety of diseases. PMID：29113792

A19571

[KO Validated] c-Myc Rabbit mAb

A11145

[KO Validated] CDK9 Rabbit mAb

A19588

CTCF Rabbit mAb

Target

Cat.No.

Product Name

Application

Reactivity

TP53	A0263	p53 Rabbit pAb	WB,IHC-P,IF/ICC,IP	Human, Rat
CDK9	A11145	[KO Validated] CDK9 Rabbit mAb	WB,IHC-P,IF/ICC,IP,ChIP,ChIP-seq,CUT&Tag	Human, Mouse, Rat
E2F6	A11546	E2F6 Rabbit mAb	WB,IP,ChIP	Human
YY1	A12928	YY1 Rabbit pAb	WB,ChIP	Human, Mouse, Rat
TEAD1	A13366	TEAD1 Rabbit pAb	WB,IHC-P,IF/ICC,ChIP	Human, Mouse, Rat
IKZF1	A1850	Ikaros Rabbit pAb	WB,IF/ICC,ChIP	Human, Mouse, Rat
MYC	A19032	[KO Validated] c-Myc Rabbit mAb	WB,ChIP,CUT&Tag	Human, Mouse
RXRA	A19105	RXRα Rabbit mAb	WB,IF/ICC,IP,ChIP	Human, Mouse, Rat
SMAD4	A19116	[KO Validated] Smad4 Rabbit mAb	WB,IHC-P,IP,ChIP,CUT&Tag	Human, Mouse, Rat
YY1	A19569	YY1 Rabbit mAb	WB,IF/ICC,IP,ChIP	Human, Mouse, Rat
CTCF	A19588	CTCF Rabbit mAb	WB,IF/ICC,IP,ChIP,CUT&Tag,ChIP-seq	Human, Mouse, Rat
SP1	A19649	SP1 Rabbit mAb	WB,IHC-P,IF/ICC,ChIP	Human, Mouse, Rat
FOXM1	A2493	FOXM1 Rabbit pAb	WB,ChIP	Human, Mouse, Rat
E2F6	A2718	E2F6 Rabbit pAb	WB,IF/ICC,IP,ChIP	Human
TFAM	A3173	TFAM Rabbit mAb	WB,IHC-P	Human, Mouse, Rat
NRF1	A3252	NRF1 Rabbit mAb	WB,IHC-P,IP,ChIP	Human, Mouse, Rat
YBX1	A3534	YB-1/YBX1 Rabbit mAb	WB,IHC-P,IF/ICC,IP,ChIP	Human, Mouse, Rat
IKZF1	A3565	Ikaros Rabbit mAb	WB,IF/ICC,ChIP	Human, Mouse
HMGA1	A4343	HMGA1 Rabbit mAb	WB,IHC-P,IF/ICC,ChIP	Human, Mouse, Rat
TEAD1	A5218	TEAD1 Rabbit mAb	WB,IP,ChIP	Human, Mouse, Rat
ELF3	A5236	ESE1/ELF3 Rabbit mAb	WB,ChIP	Human, Mouse, Rat
JUND	A5433	JunD Rabbit mAb	WB,IP,ChIP	Human, Mouse, Rat
NRF1	A5547	NRF1 Rabbit pAb	WB,ChIP	Human, Mouse, Rat

DNA methylation antibodies

DNA methylation is a conserved epigenetic modification that is important for gene regulation and genome stability. Aberrant patterns of DNA methylation can lead to plant developmental abnormalities. A specific DNA methylation state is an outcome of dynamic regulation by de novo methylation, maintenance of methylation and active demethylation, which are catalysed by various enzymes that are targeted by distinct regulatory pathways. PMID:29784956

A20599

5-Methylcytosine (5mC) Rabbit mAb

A19679

[KD Validated] DNMT1 Rabbit mAb

A19659

[KO Validated] DNMT3A Rabbit mAb

RNA modification antibodies

An emerging body of evidence indicates that post-transcriptional gene regulation relies not only on the sequence of mRNAs but also on their folding into intricate secondary structures and on the chemical modifications of the RNA bases. These features, which are highly dynamic and interdependent, exert direct control over the transcriptome and thereby influence many aspects of cell function. PMID:28144031

A19841

N6-methyladenosine / m6A Rabbit mAb